What does the research say?

I don’t think it takes a science degree to see that this idea is based on flimsy science at best, and wishful thinking and good marketing at worst.

What is it supposed to do?

Myostatin is a member of a superfamily of related compounds known as “transforming growth factors beta.” They are intimately related to tissue growth and differentiation, as well as many other functions. What scien- tists discovered was by knocking out the gene that codes for myostatin (the famed “myostatin gene”), animals would grow up hugely muscular. One needs only to see pictures of that ridiculously muscular mouse in the supplement ads to know what I mean.

So the idea behind these supplements is that blocking myostatin will en- able muscle growth.

What does the research say?

Scientists have been looking at these growth factors, what regulates them, what genes code for them, etc. since it may have applications to grow live- stock with greater amounts of meat and less fat, or combating wasting syndromes in humans, such as AIDS, cancer, and muscular dystrophy.

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For example, high levels of myostatin have been associated with muscle wast- ing in HIV-infected men compared to healthy normal men.

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However, this simple association does not in anyway prove myostatin directly contrib- utes to muscle wasting, per se. It may simply be an intermediate indicator vs. a direct cause.

Myostatin may be one way the body regulates lean tissue growth (muscle) and appears to be a direct inhibitor of skeletal muscle growth, at least in prenatal sustanon 300 side effects body-muscles.com and perhaps growing animals, but its the relevant folk remedies for the treatment of crossfit effects in adult animals much less adult humans is very poorly understood at this time. Further

body regulates

research is needed to determine whether myostatin even plays a role in muscle growth after birth and in adults.

Relating to bodybuilders and other athletes, one theory is that the reason some people put on muscle so much easier than others is that they have a genetic propensity for making less myostatin due to a mutation in the gene. Conversely, the reason some people find it almost impossible to add muscle might be that they are genetically set up to have high levels of myo- statin and, therefore, their efforts in the gym are being blocked.

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That overly simple theory is all well and fine, but data has been contradictory at best.

One group of researchers compared different groups legal exercises for chronic prostatitis beneficial of people to their level of muscularity and race and found that mutations in the human myo- statin gene had little impact on responses in muscle mass to strength train- ing. The fact is, muscle regeneration of injured skeletal muscle tissue, that is exactly how muscle heals itself in response to say weight training, is an extremely complex system that is not well understood.

To say that scientists, much less supplement companies, don’t fully under- stand the roles of myostatin in exercise-induced muscle hypertrophy or re-

generation following exercise, is putting it mildly.

adult humans

Yes, myostatin probably plays an essential role as a regulator of LBM in adult humans as recent data would seem to suggest, but again, what role and how, is still be elucidated.

Ok, bottom line here is, scientists know very little about how or if myostatin plays a direct role in muscle tissue of adult healthy human athletes. It’s also absolutely essential that people understand that all such systems in the human body are under the control of an immensely complicated system of checks and balances, multi-layered feedback pathways, some of which are known, many of which are not.

There is a reason the body regulates anabolic and catabolic processes so tightly, and altering that very delicate balance can have unforeseen long- term effects.

It’s interesting to note that one pharmaceutical company has applied for a patent (United States Patent #6,369,201) that is an antibody to myostatin, and would reduce myostatin levels.

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There is no doubt that the research looking into the effects of myostatin on LBM of healthy and sick people is

an interesting and worthwhile pursuit by researchers, but as a supplement to spend money on, it is premature to say the least.

this time

The current crop of supplements contain sulfated polysaccharides from brown seaweed (Cystoseira canariensis). Why brown seaweed? This is be- cause polysaccharides isolated from brown seaweed were found to bind to serum myostatin buy equipoise in australia boldenone undecylenate in an in-vitro (test-tube) experiment.

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Needless to state, what happens in a test tube can be quite different from what happens when a compound is consumed and digested.

This was demonstrated rather conclusively by a 2004 study that fed 1200 mg/day of a commercial myostatin inhibitor to untrained males participat- ing in a 12 week resistance training program. The study concluded:

“Twelve wk of heavy resistance training and 1200 mg/d of Cystoseira canar- iensis http: body-muscles.com supplementation appears ineffective at inhibiting serum myostatin and increasing muscle strength and mass or decreasing fat mass.”

What does the real world have to say?

Do you even need to ask? Commercial supplements based on Cystoseira canariensis (a.k.a. brown seaweed) are quietly fading into oblivion.


There has been mention in the mags of an in vivo study with people, with results on LBM that seemed far too good to be true (what else is new!). Until such a study is published in a peer reviewed Western/legit journal (most scientists have little faith in Eastern Bloc research or journals as they often lack the same stringent quality control western research/journals are subjected to) by an independent source not associated with the company making these supplements, I see no reason for people to spend their hard earned money on such a product at this time.

Perhaps companies selling these supplements will fund some studies in adult humans showing they have some effects on muscle mass, strength, or performance, but until then, they get a big thumbs down from me at this time.